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diabetic blindness icd 10 Matsuzaka et al. (2007) reported that Elovl6 (611546) -/- mice developed obesity and hepatosteatosis when fed a high-fat diet or when mated to leptin-deficient (ob/ob) mice, but showed marked protection from hyperinsulinemia, hyperglycemia, and hyperleptinemia. Amelioration of insulin resistance was associated with restoration of hepatic insulin receptor substrate-2 (IRS2; 600797) and suppression of hepatic protein kinase C-epsilon (PRKCE; 176975), resulting in restoration of Akt (see 164730) phosphorylation. Matsuzaka et al. (2007) noted that the Elovl6 -/- mice were unique in that their insulin resistance was reduced without the amelioration of obesity or hepatosteatosis, and concluded that hepatic fatty acid composition is a new determinant for diabetic blindness icd 10 insulin sensitivity that acts independently of cellular energy balance and stress.

diabetic blindness icd 10

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